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Semaglutide Injection

A once-weekly GLP-1 receptor agonist that may help reduce appetite and support weight management when prescribed by a licensed healthcare provider.

From $169/month
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How Semaglutide Works

Semaglutide is a GLP-1 receptor agonist that mimics a natural hormone involved in appetite regulation and blood sugar control.

Reduces Appetite

Acts on brain receptors involved in hunger signaling, which may help reduce food intake.

Slows Gastric Emptying

May help you feel fuller longer by slowing how quickly food leaves the stomach.

Supports Blood Sugar

Helps regulate blood sugar levels by stimulating insulin release in response to meals.

Typical Dosage Schedule

Your healthcare provider determines the appropriate dosing for your individual needs. The schedule below is a general guideline.

Weeks 1–4
0.25 mgInitiation

Low starting dose to help your body adjust. Most patients experience minimal side effects.

Weeks 5–8
0.5 mgEscalation

Gradual dose increase as your body acclimates to the medication.

Weeks 9–12
1.0 mgEscalation

Continued dose escalation toward the therapeutic range.

Weeks 13–16
1.7 mgEscalation

Approaching maintenance dose. Most patients see meaningful progress by this phase.

Week 17+
2.4 mgMaintenance

Full therapeutic dose. Your provider may adjust based on your individual response.

Potential Side Effects

Like all medications, semaglutide may cause side effects. Most are mild and improve over time. Discuss risks and benefits with your provider.

Nausea

Common

Usually mild, improves as your body adjusts. Most common during dose escalation.

Constipation or diarrhea

Common

Digestive changes are typical and often resolve within the first few weeks.

Headache

Common

Usually mild and temporary.

Fatigue

Less common

Some patients report mild fatigue during the initial weeks.

Injection site reactions

Less common

Minor redness or discomfort at the injection site.

This is not a complete list of side effects. Serious side effects are rare but possible. Contact your healthcare provider or seek emergency care for severe symptoms.

Clinical Evidence

Published clinical trial data for FDA-approved semaglutide (Wegovy). Compounded semaglutide has not been independently evaluated in clinical trials.

~15%

Average body weight reduction

In the STEP 1 trial, participants receiving 2.4 mg semaglutide weekly lost an average of ~15% of body weight over 68 weeks vs. ~2.4% with placebo.

Wilding et al., NEJM 2021

1,961

Participants in STEP 1

The landmark STEP 1 trial enrolled 1,961 adults with BMI ≥30 (or ≥27 with comorbidity), demonstrating significant weight reduction.

STEP 1 Trial, NCT03548935

86%

Achieved ≥5% weight loss

86.4% of semaglutide participants achieved at least 5% weight loss compared to 31.5% in the placebo group.

Wilding et al., NEJM 2021

These results are from clinical trials of FDA-approved semaglutide (Wegovy), not compounded semaglutide. Compounded medications are not FDA-approved and have not been evaluated in equivalent clinical trials. Individual results may vary. All participants also received lifestyle counseling.

What to Expect

A general guide based on published clinical data for FDA-approved semaglutide. Your experience may differ.

1
Weeks 1–4

Adjustment Period

Starting dose helps your body adapt. Most patients notice reduced appetite and fewer cravings. Mild nausea is common but typically resolves.

2
Months 2–3

Early Progress

As doses increase, appetite regulation becomes more noticeable. In clinical trials, meaningful weight changes typically began during this period.

3
Months 4–6

Sustained Results

Patients at maintenance dose often report stabilized appetite, improved energy, and continued progress. Provider monitors and adjusts as needed.

4
Month 6+

Long-Term Management

Ongoing treatment supports sustained progress. Regular check-ins with your provider ensure optimal dosing and monitoring.

Results may vary. This timeline is illustrative and based on published data for FDA-approved semaglutide. No specific outcome is guaranteed with compounded medications.

Simple, Transparent Pricing

Provider consultation, medication, and shipping included. Cancel anytime.

Most Popular

$169/mo

First month (52-week plan). Then $289/mo month-to-month.

  • Licensed clinician consultation
  • Compounded semaglutide injection
  • Free priority shipping
  • Ongoing provider support
  • Monthly dose adjustments
  • No insurance required
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Frequently Asked Questions

What is compounded semaglutide?
Compounded semaglutide is prepared using semaglutide as the active pharmaceutical ingredient (API) by a state-licensed 503A compounding pharmacy. It is not FDA-approved, and compounded medications are not the same as, equivalent to, or substitutes for FDA-approved medications. Your prescribing provider will determine if it is appropriate for you.
How is semaglutide administered?
Semaglutide is administered as a once-weekly subcutaneous injection. You will receive a pre-filled vial and supplies with instructions. Most patients inject into the abdomen, thigh, or upper arm.
Who is eligible for semaglutide?
Eligibility is determined by a licensed healthcare provider based on your medical history and health profile. Generally, candidates have a BMI of 27+ with a weight-related comorbidity or BMI of 30+. Only a licensed provider can make prescribing decisions.
How long before I see results?
Individual results vary significantly based on starting weight, medication adherence, diet, exercise, and individual health profile. No specific outcome is guaranteed. Your healthcare provider will monitor your progress.
Can I switch to tirzepatide later?
Yes. You can discuss switching medications with your healthcare provider at any time. Changes take effect at your next billing cycle.
What if I experience side effects?
Contact your healthcare provider if side effects are persistent or concerning. Your provider may adjust your dosage or recommend management strategies. For serious adverse events, seek immediate medical attention.

Related Reading

Learn more from our clinical resource library.

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Compounded semaglutide is not FDA-approved and has not been evaluated by the FDA for safety, efficacy, or quality. It is not the same as, equivalent to, or a substitute for FDA-approved brand-name products (e.g., Ozempic, Wegovy). Compounded medications are prescribed on a patient-specific basis by licensed healthcare providers and prepared by state-licensed 503A compounding pharmacies.

Individual results may vary and depend on multiple factors including starting weight, medication adherence, diet, exercise, and individual health profile. No specific outcome is guaranteed. This page does not constitute medical advice. Always consult with a qualified healthcare provider.

Blue Oak Services LLC dba Prescriva is a management services organization (MSO). All medical services are provided by independently licensed healthcare providers through our partner provider network.